Welcome to the Occlusion toolkit! The Occlusion toolkit will introduce a series of tools aimed at quantifying and understanding why PICC occlusions occur, followed by targeted approaches to reduce this adverse event. Each of the interventions listed below should be adapted sequentially in order to attain the most benefit. The tools will focus on (a) assessment of drivers of occlusion; (b) the CLOT (Catheter flush, Lumens, Optimal Access, Tip) tool to prevent and/or treat occlusion; and (c) interventions aimed at reducing rates of occlusion.